The relationship between angiotensin Ⅱ type 1 receptor gene A1166C polymorphism and chronic heart failure
- VernacularTitle:血管紧张素Ⅱ1型受体基因A1166C多态性与慢性心力衰竭的相关性研究
- Author:
Xiaoming ZHENG
;
Junshuang LIU
;
Hongfen LI
;
Ying LIU
- Publication Type:Journal Article
- Keywords:
Heart failure;
Angiotensin Ⅱ type1 receptor;
Gene polymorphism
- From:
Clinical Medicine of China
2008;24(5):461-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship of angiotensin Ⅱ typel receptor gene A1166C polymorphism and chronic heart failure.Method Polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP)was used to detect the A1166C polymorphism of AT1R gene of 135 chronic heart failure patients and 121 controls.Results The genotype frequency of the patients and controls of AA,AC,CC were 87.6%.12.4%,0%and 87.6%,11.6%,0.8%respectively.Allele frequency of the patients and controls were 93.8%,6.2%and 93.6%,6.4%respectively.There was no significant difference of the frequency of AT1R genotype and allele between CHF and controls(P＞0.05).Conclusion Angiotensin Ⅱ type 1 receptor gene A1166C polymorphism is not associated with CHF.
