Mesenchymal stem cells: their phenotype, immunological features, and potential for homing
- VernacularTitle:间充质干细胞的表型、免疫学特性及归巢潜能
- Author:
Qiangfeng YU
;
Jianyin ZHOU
;
Xiaomin WANG
- Publication Type:Journal Article
- Keywords:
mesenchymal stem cells;
immunobiology;
homing;
chemokine receptors;
adhesion molecules
- From:
International Journal of Surgery
2008;35(5):327-329
- CountryChina
- Language:Chinese
-
Abstract:
Mesenehymal stem cells CMSCS are nonhematopoietie stromal cells that are capable of differentiating into, and contribute to the regeneration of, mesenchymal tissues such as bone, cartilage, muscle, ligament, tendon and adipose. MSCs have been isolated from human first- and second-trimester fetal blood, liver, spleen, bone marrow, adipose tissue, amniotie fluid, periosteum and embryo. Not only can they express many phynotypes involving adhesion molecules and chemokine receptors, but also have character of immune tolerance, so they have potential of migration and transportation to target issue and feature of immune suppressing. There are wide application prospects for a number of areas in the cardiovascular, neurological, blood, surgical injury and other diseases. The current review describes the phynotypes, the immune tolerance and the potential for homing of MSCs.
