The effect of single nucleotide polymorphism in interleukin-1 gene on the susceptibility of ankylosing spondylitis in Chinese Han population
- VernacularTitle:白细胞介素-1的基因单核苷酸多态性对中国汉族人强直性脊柱炎易感性的影响
- Author:
Huan LIU
;
Xiaodong KONG
;
Qing CAI
;
Huiqi LU
;
Feng QIAN
;
Xiaoping YANG
;
Zhen XU
;
Huji XU
- Publication Type:Journal Article
- Keywords:
Spondylitis,ankylosing;
Interleukin 1;
Polymorphism;
Gene
- From:
Chinese Journal of Rheumatology
2008;12(5):304-308
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine the suscepribility of the single nucleotide polymorphisms(SNPs)in IL-1 gene in Chinese Han population to ankylosing spondylitis (AS). Methods An correlation analysis was performed in a case-control cohort of 162 AS cases, 58 patients with other autoimmune diseases and 162 controls. Four SNPs located in the IL-1 gene (rs16944, rs3811058, rs419598, rs315952) were examined by polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP). Results The frequencies of allele C at position rs16944, rs3811058, rs419598 significantly increased in AS cases VS controls, so did their genotype frequencies (50% vs 36.3%, 57.9% vs 52.8%, 45.7% vs 12.3%, P＜0.05). The SNPs of these sites significantly influenced the prevalence of AS. Conclusion We discover that SNPs of IL-1 gene Rs16944, Rs419598, Rs3811058 is closely related to the occurrence of AS.
