Evaluate the effect to omeprazole in preventing treatment of hypertensive cerebral hemorrhage with stress ulcer bleeding
- VernacularTitle:奥美拉唑对脑出血应激性溃疡的预防效果
- Author:
Fengying DING
;
Weiliang LUO
- Publication Type:Journal Article
- Keywords:
Intracranial hemorrhage,hypertensive;
Omeprazole;
Peptic ulcer;
Stress
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(4):614-615
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of omeprazole in preventing treatment of hypertensive cerebral hemorrhage with stress ulcer bleeding. Methods A total of 100 patients with hypertensive cerebral hemorrhage were treated with conventional therapy including dehydration, antihypertensive and supporting treatment. The patients were randomly divided into omeprazole group(n=50) and control group( n = 50). The control group received conventional therapyonly, while the omeprazole group received additional omeprazole 40mg, iv, qd, for 14d. Results Omeprazole group stress ulcer 6 eaess(12.0% ) was significantly lower than the control group 12 cases(24.0% );two groups stress ulcer incidence of severity are increasing with the increase of the disease; the mortalities of cerbral hemorrhage were 6.0 % in the omeprazole group and 16.0 % in the control group and the difference had significant meaning(P＞0.05). Conclusion Omeprazole has significant beneficial effect in preventing upper gastrointestinal hemorrhage after hypertensive cerebral hemorrhage.
