Association of the monocyte chemoattractant protein-1 -2518A/G gene polymorphism with coronary lesions and in-stent restenosis after percutaneous coronary intervention
- VernacularTitle:单核细胞趋化蛋白-1基因多态性与冠状动脉介入治疗后再狭窄的相关性研究
- Author:
Jing GAO
;
Rangzhuang CUI
;
Yin LIU
;
Qian CHEN
;
Minxin WEI
;
Fumei ZHAO
;
Yuqian LI
;
Junyi ZHEN
;
Ting LIU
- Publication Type:Journal Article
- Keywords:
Coronary diseases;
Monocyte chemoattractant protein-1;
Polymorphism(genetics);
Gene;
Restenosis
- From:
Chinese Journal of Geriatrics
2008;27(5):321-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of monocyte chemoattractant protein-1 (MCP-1) promoter -2518A/G gene polymorphism with coronary lesions and in stent restenosis in Tianjin Chinese population. Methods Two hundred and seventy six patients who underwent percutaneous coronary intervention (PCI) and coronary angiography during follow-up were enrolled in the study. The MCP-1 gene promoter polymorphism at position -2518 was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results The frequencies of three genotypes of MCP-1-2518A/G polymorphism were 21.0% AA, 34. 1% GG,44.9% AG, respectively. There were no statistical differences in the number and the mean degree of stenosis vessels before PCI among 3 genotype groups (all P＞0.05). 113 cases developed in-stent restenosis and 163 cases were free from restenosis. In restenosis group, the AA, AG and GG genotype frequencies were 23.9%, 40.7%, 35.4%, against 19.0%, 47.9% and 33.1% in nonrestenosis group (P = 0. 446) . The frequencies of -2518A and G allele were 44.2%, 55.8% in restenosis group versus 42.9%, 57. 1% in non-restenosis group(P=0. 761). Conclusions The polymorphism of MCP-1-2518 A/G gene may be associated with neither atherosclerosis nor the in-stent restenosis.
