The changes of barrier of gut in severe hepatitis
- VernacularTitle:重症肝炎患者肠道屏障功能的变化
- Author:
Dongyan LIU
;
Xueheng LU
;
Pei LIU
- Publication Type:Journal Article
- Keywords:
Hepatitis;
Barrier of gut;
IgA;
secretory component;
ZO-1;
Occludin
- From:
Clinical Medicine of China
2008;24(5):412-414
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of IgA,secretory component(SC)and ZO-1,occludin of gut in severe hepatitis and to understand the reason of abdomen symptom in severe hepatitis patients.Methods IgA,SC,ZO-1 and occludin of gut were assayed by immunohistochemistry.Results Compared with the controls,the staining of IgA,SC,ZO-1 and occludin in severe hepatitis were notably decreased.Conclusion In severe hepatitis,IgA,SC,ZO-1 and occludin expression of gut decrease,leading to the abnormality of barrier of gut,which is one the reasons of resuhings in abdomen symptoms in severe hepatitis.
