Comparison of the Bard BTA Stat Test and Cytology in the Diagnosis and Follow-up of Bladder Cancer.
- Author:
Young Beom JEONG
1
;
Hyung Jin KIM
Author Information
1. Department of Urology, Chonbuk National University Medical School, Chonju, Korea.
- Publication Type:Original Article
- Keywords:
Bladder neoplasms;
Cytology;
BTA
- MeSH:
Cystoscopy;
Diagnosis*;
Follow-Up Studies*;
Healthy Volunteers;
Hematuria;
Humans;
Immunochromatography;
Sensitivity and Specificity;
Urinary Bladder Neoplasms*;
Urinary Bladder*
- From:Korean Journal of Urology
1999;40(7):891-895
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The BTA stat test is a one-step immunochromatographic assay to detect bladder tumor antigen in the urine. We evaluated the efficacy of the BTA stat test and bladder wash cytology(BWC) in the detection and follow-up of bladder cancer. MATERIALS AND METHODS: A voided urine sample for BTA stat test and bladder washing urine for cytology were obtained. The BTA stat test with or without BWC was performed in normal volunteers(n=20), patients with hematuria of unknown origin(n=29), patients with benign genitourinary(GU) disease(n=17), patients with other GU cancer(n=12), patients with bladder cancer(n=46) and patients with a history of bladder cancer(n=54). RESULTS: The overall sensitivities of the BTA stat and BWC in bladder cancer were 69.6% and 41.3%, respectively(p<0.01). For T2 or higher stage tumors, sensitivity was 94.1% for BTA stat and 64.7% for BWC(p<0.05). Grade II tumors were detected at 64.3% with BTA stat and 35.7% with BWC(p<0.05). The sensitivities of the BTA stat and BWC in the follow-up of patients after transurethral resection of bladder tumor were 45.5%(5/11) and 27.3% (3/11), respectively. The specificities of the BTA stat and BWC in the same patients were 88.4%(38/43) and 100%(43/43), respectively(p<0.05). The specificity in patients with hematuria but without disease was 69% for BTA stat and 100% for BWC. The specificities of the BTA stat in healthy volunteers, benign GU disease and other GU cancer were 95%, 82.4% and 75%, respectively. CONCLUSIONS: Our results demonstrate that BTA stat test is a simple, noninvasive test that is superior to bladder wash cytology for detection of bladder cancer in its sensitivity and a useful adjunct of cystoscopy in surveillance and diagnosis of bladder cancer. However, the BTA stat test can not replace cystoscopy due to low specificity.
