β-catenin mutation in pediatric malignant tumors
- VernacularTitle:小儿恶性肿瘤β-catenin基因突变的研究进展
- Author:
Zheng ZHAO
;
Huanmin WANG
- Publication Type:Journal Article
- Keywords:
pediatric tumors;
β-catenin;
CTNNB1;
mutation
- From:
International Journal of Surgery
2008;35(4):268-270
- CountryChina
- Language:Chinese
-
Abstract:
β-catenin is an important signaling transduetion and adhesion molecules.Mutation of the betacatenin gene,CTNNB1,is a common case in pediatric tumors,which may induce development and metastasis.In hepatoblastoma,48%have CTNNB1 mutation.In Wilms tumor,mutation only occurs in cases with WT1 gene mutation.In neuroblastoma,mutation is also found.
