Clinical significance of peripheral blood leukocyte and lymphocyte function-associated antigen-1 expression in renal allograft recipients
- VernacularTitle:肾移植受者外周血白细胞淋巴细胞功能相关抗原-1表达的意义
- Author:
Han BAI
;
Guanghui PAN
;
Licheng JIANG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Leukocytes;
Antigens
- From:
Chinese Journal of Organ Transplantation
2000;21(1):38-39
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To inspect the levels of peripheral blood leukocyte and lymphocyte functionassociated antigen-1(LFA-1)expression in renaI allograft recipients before and after renal transplantation.Methods Using monoclonal antibody-flow cytometer fluorescence technique,the expression of LFA-1 in lymphocytes of 33 patients with renal transplantation was detected at 1 day before operation and 3,6,9,15 days after operation by flow cytometric immunological technique,Results The level of LFA-1 expression after transplantation was significantly decreased and maintained at a low level.and ascended suddenly during the course of graft rejection.The level of LFA-1 expression in rejection was obviously higher than in non-rejection and after the eontrollring of rejection.Conclusions LFA-1 might Dlay an important role in graft rejection.Monitoring of the expression of LFA-1 is helpful for the diagnosis of the graft rejection.
