Immunological regulation of mesenchymal stem cell
- VernacularTitle:间充质干细胞免疫调节作用研究进展
- Author:
Zaifa HONG
;
Xiaomin WANG
- Publication Type:Journal Article
- Keywords:
mesenchymal stem cell;
immunological regulation;
immune suppression
- From:
International Journal of Surgery
2008;35(5):318-321
- CountryChina
- Language:Chinese
-
Abstract:
Besides the haemopoietic stem cell, mesenchymal stem cell (MSC) is an adult stem cell in the marrow. It has the ability to self-renew, differentiate into various kinds of tissue and regulate the immunological system. MSC possess low immunogenicity. It shows the immunosuppressive ability in vitro and has function of inducing immune-tolerance. MSC suppress accrementition of T cell respone to the allotigen and mitogen and hinderes the development of cytotoxic T lymphocyte cell. In addition, MSC can influence antigen presenting cell, natural kill cell, B cell, and so on.
