Genotypic characteristics of hepatitis B virus isolated from 60 Tibet patients
- VernacularTitle:西藏地区60例慢性乙型肝炎患者病毒基因分型及分布特点
- Author:
Xuehong GONG
;
Jinlei WANG
;
Chengyan MENG
;
Jialin JIN
;
Wenhong ZHANG
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Hepatitis B,chronic;
Genotype;
Tibet
- From:
Chinese Journal of Infectious Diseases
2008;26(5):309-312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genotypic characteristics of hepatitis B virus(HBV) in Tibet.Methods Serum samples from 60 cases of hepatitis B in Tibet Autonomous Region were collected from January 2000 to March 2004.HBV genotypes were analyzed by sequencing S region and precore/core region.Results HBV isolated from 60 cases were all found to be D genotype by S region sequencing.Dc mixture was found in 59 cases,showing the recombination between their precore/core gene and genotype B virus at 1804-2299 nucleotide.The other one case showed Dbc mixture genotype,showing recombination between its precore/core gene and genotype B and C genes.Conclusions All Tibet cases in this study show mixture genotype D with recombination with genotvpe C or both genotype B and C at precore/core region.No case of pure genotype D is found.
