Effects of on-pump and off-pump coronary artery bypass grafting on plasma adrenomedullin and endothelin-1 levels in elderly patients
- VernacularTitle:两种冠状动脉旁路移植术对老年患者血浆肾上腺髓质素和内皮素-1的影响
- Author:
Guangqing CAO
;
Shuming WU
;
Xiquan ZHANG
;
Yongmei WANG
;
Shanshan DUAN
;
Min ZHOU
;
Ye LIU
- Publication Type:Journal Article
- Keywords:
Coronary artery bypass grafting;
Cardiopulmonary bypass;
Adrenomedullin;
Endothelin-1
- From:
Chinese Journal of Geriatrics
2008;27(5):325-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of on-pump and off-pump coronary artery bypass grafting on plasma adrenomedullin (ADM) and endothelin-1 (ET-1) levels before and after operation in elderly patients. Methods Elderly patients aged 60 years and over with coronary artery bypass grafting were enrolled in the study and divided into off-pump group and on-pump group, each group had 20 cases. Blood samples were collected before surgery, immediately after operation and 6,24 hours, 3 days after operation. The plasma levels of ADM and ET-1 were dectecded by radio immunoassay. Results The levels of ADM and ET-1 were significantly increased immediately after operation in 2 groups of on-and off-pump. The levels of ET-1 in on-pump group and off-pump group were (67.59±10.18) ng/L and (58.73±9.64) ng/L respectively. The levels of ADM in on-and off-groups were (284.90±36.24) ng/L and (243.25±25.70) ng/L. This showed that in on-pump group, the plasma levels of ADM and ET-1 increased more significantly(P＜0.05). The plasma levels of ADM and ET-1 began to decline at 6 hours after operation, and continued to 24 hours after operation. On 3 days after operation, the plasma levels of ADM and ET-1 in off-pump group returned to the preoperative level, but they were still maintained at a high level in on-pump group.Conclusions For elderly patients, both on-pump and off-pump coronary artery bypass grafting can cause endothelial dysfunction, increasing plasma levels of ET-1 and ADM. But compared with the on-pump coronary artery bypass grafting, the off-pump coronary artery bypass grafting has less influence.
