Effect of resveratrol on apoptosis and cell cycle of human esophageal cancer Eea109 cells
- VernacularTitle:白藜芦醇诱导人食管癌Eca109细胞凋亡及其对细胞周期的影响
- Author:
Yongjun LI
;
Xiaohui SUN
- Publication Type:Journal Article
- Keywords:
Esophageal cancer;
Resveratrol;
Apoptosis;
Eca109 cell
- From:
Clinical Medicine of China
2008;24(5):420-422
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate human esophageal cancer Eca109 cells apoptosis induced by resveratrol.Methods Eca109 cells were treated with difierent concentrations of resveratrol and the change of morphology was observed by inverted microscope and transmission electron microscope in different time;The cell growth inhibitory rate of resveratrol on the proliferation of Eca109 cells were evaluated in vitro by MTT assay.Flow cytometry (FCM)analysis was used to determine the apoptosis of Eca-109 cells.Results Resveratrol was able to inhibit the growth of Eca109 cells,and the suppressive effect was increased with treating concentration and treating time.Resveratrol inhibited the growth of esophageal cancer Eca109 cells in a dose-and time-dependent manner and induced the apoptosis in esophageal cancer.Conclusion Resveratrol could inhibit the proliferation of Eca-109 cells and block the cell cycle at G0/G1.And in the end resveratrol could induce the apoptosis of Eca109 cells.
