Expression of cox-2 in human colorectal carcinoma and its clinical significance
- VernacularTitle:大肠癌组织中COX-2的检测及其临床意义
- Author:
Weiguo XU
;
Jining SONG
;
Xiaoqing YANG
;
Shizhu HAO
;
Chanchan HU
;
Ming LI
;
Chuntao WU
;
Hongcheng ZHU
;
Ruiwei LI
;
Guangming ZHAO
- Publication Type:Journal Article
- Keywords:
Colorectal carcinoma;
COX-2;
CD105;
MVD;
Angiogenesis
- From:
Clinical Medicine of China
2008;24(5):436-438
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether cyclooxygenase-2(COX-2)expression are related to the clinicopathological features,and to microvessel density(MVD).Methods COX-2 expressions were detected in 45colorectal carcinoma samples by immunostaining.MVD was evaluated with the specific antibody CD105.Quantitationof COX-2 mRNA was performed by RT-PCR in 45 specimens of colorectal carcinoma.Results The expressions of COX-2 mRNA and protein were significant variation among lymphatic metastasis,high Dukes stages and grade of differation(P＜0.05);Increased value of MVD were significant variation among lymphatic metastasis,high Dukes stage and depth of tumor invasion(P＜0.05).Both the overexpression of COX-2 protein and mRNA was positively correlated with the value of MVD(P＜0.05).Conclusion COX-2 plays an important role in the development of colorectal carcinoma.COX-2 may up-regulate the value of MVD,which induces angiogenesis and accordingly contributes to metastasis.
