Expression of Stat 3, GluT-1 and PCNA in condylomata acuminata
- VernacularTitle:转录激活因子3、葡萄糖转运蛋白-1、增殖细胞核抗原在尖锐湿疣组织中的表达
- Author:
Guangwen YIN
;
Bingjie CAI
;
Min LI
;
Shoumin ZHANG
;
Yaqiong YAO
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Stat 3 transcription factor;
Glucose transporter type 1;
Prolif-erating cell nuclear antigen
- From:
Chinese Journal of Dermatology
2008;41(5):301-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and significance of signal transducer and activator of transcription 3 (Stat 3), glucose transporter protein 1 (GluT-1) and proliferation cell nuclear antigen (PC NA) in lesions of condylomata acuminata (CA). Methods SP immunohistochemistry method was used to measure the expression of Stat 3, GluT-1 and PCNA in tissue samples from 40 cases of CA and 20 normal skin controls. Results The positivity rates of Stat 3, GluT-1 and PCNA were 85.0% (34/40), 87.5% (35/40) and 85.0%(34/40), respectively in CA tissue, 35.0% (7/20), 30.0% (6/20)and 55.0% (11/20),respectively in the control tissue; statistical difference was observed in these rates between the two groups (all P ＜ 0.05). The expression intensity of Stat 3, GluT-1 and PCNA was also higher in CA tissue than that in the controls. In addition, the expression intensity of PCNA was correlated with that of Stat 3 and GluT-1in CA tissue (both P＜ 0.05). Conclusions There is an overexpression of Star 3, GluT-1 and PCNA in CA tissue, and the overexpression of Stat 3 and GluT-1 may be associated with the over-proliferation of CA tissue.
