Effects of Hydroxyethyl starch on hemodynamics and coagulation during cardiopulmonary bypass
- VernacularTitle:羟乙基淀粉对体外循环血流动力学及凝血的影响
- Author:
Jianmin QIAO
;
Ruili YAO
;
Libing GAO
;
Weisan WANG
- Publication Type:Journal Article
- Keywords:
Cardiopulmonary bypass;
Hydroxyethyl starch;
Hemodynamics;
Coagulation
- From:
Clinical Medicine of China
2008;24(5):425-427
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of 6%hydroxyethyl starch(Volven 130/0.4)infusion on hemodynamics and coagulation.Methods 60 cases of open heart surgical children under cardiopulmonary bypass were randomly divided into two groups(30 cases for each):The control group(group C)were infused with 400 ml plasma and volven group(group V)were infused with 400 ml Volven before cardiopulmonary bypass.Then mean aterial pressrue(MAP),heart rate(HR),and central venous pressure(CVP)were measured.The venous blood samples were collected before and after infusion for the measurements of the following parameters:haematocrit(HCT),blood sedimentation(BSR),platelet count(PLC),prothrombin time(PT),and activated whole blood clot time(ACT).Those indexes before operation,15 min after bypass,after returning to ICU,and 24 hours after operation were observed.Results HCT and PLC after infusion were significantly lower than that before infusion.BSR after infusion was significantly faster than that before infusion.There were no significant changes in MAP,HR,CVP,PLC,ACT and PT.Conclusion 6%Hydroxyethyl starch infusion is safe and beneficial during cardiopulmonary bypass.
