Effects of long-term enhanced external counterpulsation on endothelium-dependent and endothelium-independent vasorelaxation of the carotid arteries in atherosclerotic pigs
- VernacularTitle:体外反搏对动脉粥样硬化猪血管舒张功能的影响
- Author:
Yan XIONG
;
Xiaoxing LIAO
;
Jingyun LUO
;
Guowei CHEN
;
Xiaohong HE
;
Qiang XIE
;
Dianqiu FANG
;
Hong MA
;
Kuijian WANG
;
Zhensheng ZHENG
;
Guifu WU
- Publication Type:Journal Article
- Keywords:
Enhanced external counterpulsation(EECP);
Atherosclerosis;
Endothelium;
Vasorelaxation
- From:
Chinese Journal of Emergency Medicine
2008;17(5):469-474
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of long-term enhanced external counterpulsation(EECP)on endothelium-dependent and endothelium-independent vasorelaxation in the carotid arteries of atherosclerotic piss. Method Totally 18 20-day-old male infant pigs were randomly divided into 3 groups according to feeding given: the normal[control group(n=6),the hypercholesterolemic control group(n=6)and the hypereholesterolemic +EECP group(n=6).Porcine model of hypercholesterolemia was made by feeding high-cholesterol diet.After EECP for 36 hours in the hypercholesterolemic+EECP group(n=6),carotid arterial rings were harvested from all animals and their vaso-relaxation response to different dose of Acetylchofine(Ach)and Sodium nitroprusside (SNP)were detected,respectively.Results As the dose of Ach varying between 10-8 mol/L and 10-5mol/L, endothelium-dependent vasorelaxation ratio of hypereholesterolemic piss with or without EECP treatment was significantly lower than that of the normal control group(P＜0.05),however,endothehum-dependent vasorelax- ation ratio in pigs with EECP treatment was obviously higher compared with hypereholesterolemic pigs without EECP treatment(P＜0.05)as the Ach ranged from 10-7 mol/L to 10-5mol/L.Similarly,as the concentration of SNP ranged fiun 10-8 mol/L to 10-5 mol/L.endothelium-independent vasorelaxafion ratio of both the hypercholesterolemic control group and the hypercholesterolemic+EECP group were significantly lower than that of the normal control group(P＜0.05),and end othelium-independent vasorelaxation ratio of the hypercholesterolemic+EECP group was significantly higher than that of the hypercholesterolemic control group (P＜0.05).Condusions Long-term EECP improves the impaired endothelium-dependent and endothelium independent vasorelaxalion function resulting from atherosclerosis.
