Effects of the intrathymic injection of hepatic cells on the small intestinal allograft in rat
- VernacularTitle:肝细胞胸腺内注入对大鼠异位小肠移植物的影响
- Author:
Tao ZHAO
;
Ersitai HE
- Publication Type:Journal Article
- Keywords:
Cells;
Iniections;
Thymus gland;
Immune tolerance
- From:
Chinese Journal of Organ Transplantation
2000;21(1):47-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effects of the intrathymic injection of allohepatic cells on intestinal allograft.Methods Adult male DA and PVG rats,7-9 week old,were used as donors and recipients,respectively.The ectopic small howel transplantations were performed one week after intrathymic injection of hepatic cells without use of any immunosuppressants.The surgical procedures were carried out in a such manner that portal vein was anastomosed with 1eft renal vein by the cuff,aorta was anastomosed with superior mesenteric artery with its aortic patch.Results The donor liver ceils could survive in the recipient thymus for 3 weeks.The small intestinal allograft showed severe rejection and donor died one week after intrathymic injection of hepatic cells,but the hepatic cells could survive within the thymus at this time.Conclusion The intrathymic injection of allohepatic cells could not induce immune tolerance of the recipient to the same donor small intestinal graft.
