Assessment of serum hormones and survey on quality of life in prostate cancer patients after androgen deprivation therapy
- VernacularTitle:前列腺癌药物去势后早期血清激素变化与生活质量评估
- Author:
Dongliang YAN
;
Xiaowen SUN
;
Enping HU
;
Haitao ZHANG
;
Lei ZHANG
;
Cheng LIU
;
Hairong CAI
;
Yan ZHOU
- Publication Type:Journal Article
- Keywords:
Prostate cancer;
Androgen deprivation therapy;
Testosterone;
Prostate specific antigen;
Quality of life
- From:
Clinical Medicine of China
2008;24(5):409-411
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of medicine androgen deprivation therapy(ADT)on quality of life in patients with prostate cancer.Methods A total of 42 consecutive advanced prostate cancer patients without any other anti-androgen medications after ADT[A subcutaneous depot injection of LHRH-agonist(Zoladex) was instituted every 28 days]were enrolled.Levels of serum testosterone and prostatic specific antigen(PSA)were obtained just prior to ADT and after ADT.The general and disease-specific health-related quality of life were assessed.Results The average testosterone level was less than 50 mg/L after medical ADT in 3 weeks.And PSA level declined dramatically in one month.Although there were no significant differences on physical discomfort and limitations to daily activities.Urinary obstruction symptoms after ADT were disappeared and the size of prostate were reduced after one month.The appetite and vigor were worsened.Overall health status and sexual function were significantly reduced.Conclusion The ADT could make serum testosterone and PSA decline dramatically in short time,and worsen some general health-related quality of life.
