Cell adhesion molecule CD15 and PECAM-1 in renal tissue during acute allograft rejection and their implication
- VernacularTitle:急性排斥反应时CD15和血小板/内皮细胞粘附分子在移植肾的表达
- Author:
Ying GUO
;
Linlang GUO
;
Wei GAO
- Publication Type:Journal Article
- Keywords:
Kidney Transplantation Immunologic factors Immunoassay
- From:
Chinese Journal of Organ Transplantation
1998;19(3):143-145
- CountryChina
- Language:Chinese
-
Abstract:
The changes in cell adhesion molecule CD15 and PECAM-1 in grafted renal tissue from 18 cases of acute allograft rejection were studied by immunohistochemistry techniques (SP method ) and computerized imaging analysis system. The results showed that: (1) CD15 positive expression level was higher in acute allograft rejection than that in normal renal in tuberular cells.(2) PECAM-1 expression level was lower in glomerular endothelial cells, but higher in tuberular cells than those in normal renal tissue during acute allograft rejection. The above findings suggested that the detection of CD15 and PECAM-1 in the grafted kidney might have some values in the diagnosis of acute allograft rejection.
