Combined use of MMF with low dosage of cyclosporine A in renal transplantation
- VernacularTitle:骁悉与小剂量环孢素A在尸体肾移植中的联合应用
- Author:
Jianyu LING
;
Yu ZU
;
Fukang SUN
- Publication Type:Journal Article
- Keywords:
Kidney/transplantation Immunosuppressive agents
- From:
Chinese Journal of Organ Transplantation
1998;19(3):175-176
- CountryChina
- Language:Chinese
-
Abstract:
In order to compare the therapeutics of combined use of MMF with low dose of cyclosporine A (CsA) in renal transplantation, 16 cases were randomly divided into 3 groups:MMF 2.0g group receiving MMF 2.0g per day, MMF 1.5g group receiving MMF 1.5g per day,and Aza group. All the patients in the 3 groups were given the low dosage of CsA and steroid.The results showed that no patients in MMF 2.0g group experienced acute rejection. One patient (20%) in MMF 1.5g group occurred twice acute rejections. In Aza group 3 out of 5 patients (60%) experienced acute rejections. Six months after transplantation, serum Cr level and the used dose of CsA in MMF 2.0g group was obviously lower than that of Aza group. It was concluded that the combined use of 2.0g MMF per day with low dosage of CsA and steroid was safe and efficacy for renal transplanted patients. The clinical results of MMF 2.0g group were superior to those of Aza group.
