Influence of thymus transplantation on T cell subsets of peripheral blood in patients with allergic rhinitis

VernacularTitle:胸腺组织移植对变应性鼻炎患者外周血T淋巴细胞亚群的影响
Author: Xiaoming CHEN ; Yanzhen JI
Publication Type:Journal Article
Keywords: Thymus gland/transplantation Rhinitis; allergic T lymphocytes
From: Chinese Journal of Organ Transplantation 1998;19(3):177-179
CountryChina
Language:Chinese
Abstract: Cultured human embryonal thymus graft was performed on 80 patients with allergic rhinitis to observe the immune function of the patients and the treatment efficiency. The thymus from the fetus of intermediate abortion was cultured for 7 to 10 days. The T cell subsets and serum antigen special IgE(sas IgE) level of the patients were determined before and after the thymus transplantation. The gross treatment efficiency is up to 92.4% among the trial patients after graft for 3 years and CD8 positive cells were increased with a significantly statistical difference (P＜0.01), and sas IgE level was much lower than before thymus transplantation (P＜0.01). It was concluded that the thymus transplantation might regulate the immune function of the patients with allergic rhinitis, including increases in the number and the function of Ts cells, and a decrease of IgE level.