Pathogenesis of cardiac injury with severe acute pancreatitis
- VernacularTitle:重症急性胰腺炎心脏损伤的发病机制
- Author:
Jianbiao XU
;
Ruochuan CHENG
;
Jianming ZHANG
- Publication Type:Journal Article
- Keywords:
severe acute pancreatitis;
cardiac injury;
pathogenesis
- From:
International Journal of Surgery
2008;35(5):329-333
- CountryChina
- Language:Chinese
-
Abstract:
In early stage of the severe acute pancreatitis, mediators of inflammation make the permeability of the microcirculation blood vessel increasing and more fluidify aggregates in tissue space. Pancreatic tissue is dropsical and necrotic ; a great quantity of body fluid accumulates in abdominal cavity, which induce utility circulation volume and returned blood volume decreasing rapidly. As more and more utility circulation volume decreases, the blood current of the coronary arterY is insufficient and the cardiac muscle cell is ischemic, the cardiac muscle is suffering injury to different extent. The cardiac load is overweight relatively. The cardiac muscle fiber is prolonged and interchanged idand cardiac muscle cellular membrane is damaged. The chain reaction and magnification of the mediators of inflammation let body delivery generous cell factors such as TNF-α,interleukin, oxygen free radical and so on, which make cardiac muscle cell's integrality damage,apoptosis,cardiac functional disturbance even exhaustion. In addition, abdominal compartment syndrome,pancreatitis associated ascetic fluid and electrolyte disturbances etc are also the important factors that affect the development of the disease.
