Correlation of polymorphism of heme oxygenase-1 gene promoter with chronic obstructive pulmonary disease and CT manifestation
- VernacularTitle:血红素氧化酶基因启动子多态性与慢性阻塞性肺疾病及胸部CT表现的关系
- Author:
Weiping FU
;
Zhihuan ZHAO
;
Lizhou FANG
;
Ling LIU
;
Jianqing ZHANG
;
Luming DAI
;
Yaping ZHANG
- Publication Type:Journal Article
- Keywords:
Chronic obstructive pulmonary disease;
Heme Oxygenase-1;
Polymorphism;
CT
- From:
Clinical Medicine of China
2008;24(5):433-436
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the mierosatellite polymorphism of heme oxygenase-1(HOX-1)gene promoter and susceptibility to chronic obstructive pulmonary disease(COPD)in Han nationality of Southwest China and CT imaging.Method The alleles frequencies with varying number of(GT)n repeatings in the Hox-1 gene in 180 smokers with COPD and in 150 healthy smokers were analyzed.Results Polymorphisms of the(GT)n repeats were grouped into three classes:S(≤25 repeats),M(26-31 repeats),L(≥32repeats).The proportion of genotypic frequencies in the group with class L alleles(L/S,L/M,I/L)was significantly higher in the smokers with COPD than in healthy smokers(29.4%vs18.7%,P=0.023,OR=1.8,95%CI 1.1-3.1).However,there was no relationship between the polymorphism of HOX-1 gene and subtypes of COPD by CT imaging in COPD patients(P＞0.05).Conclusion Genetic polymorphism in Hox-1 is associated with development of COPD in Han nationality of Southwest China.But the polymorphism of HOX-1 gene is not associated with subtypes of COPD by CT imaging.
