The effect of CsA on the morphology of the liver-the stereological analysis of the hepatic ultrastructure
- VernacularTitle:环孢素对肝细胞超微结构影响的研究
- Author:
Xiaoqing SUN
;
Ping MA
- Publication Type:Journal Article
- Keywords:
Immunosuppressive agents;
Hepatocellular;
Cytotoxi-city tests,immunologic
- From:
Chinese Journal of Organ Transplantation
2000;21(6):334-336
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of CsA in a therapeutic dose on the hepatic ultrastructure in rats.Methods Twenty-four SD rats were divided into 3 groups.The control group was orally administered olive oil,and the other 2 groups were orally given CsA 25 mg/kg and 50 mg/kg daily respectively.After 2 weeks.the liver samples were taken for ultrathin sections.The stereological method was used to quantify some hepatic ultrastructural parameters including volume density (Vv),surface density(Sv),numerical density(Nv) and specific surface(δ).Results CsA caused an increases of Vv and Sv and a decrease of δ in endoplasmic reticulum;a decreases of Vv and Nv in microbody;decreases of Vv in Golgi complex and glycogen inclusions;an increases of Vv and Nv in lipid inclusions.Conclusion CsA in a therapeutic dose could cause the change of hepatic ultrastructure of rat.
