The treatment of acute liver failure by auxiliary partial orthotopic liver transplantation in rats
- VernacularTitle:大鼠原位辅助性肝移植治疗急性肝功能衰竭
- Author:
Minde LUO
;
Yeqin YU
;
Zhaoyou TANG
- Publication Type:Journal Article
- Keywords:
Liver/transplantation;
Acute liver failure;
Animal model
- From:
Chinese Journal of Organ Transplantation
1998;19(2):79-81
- CountryChina
- Language:Chinese
-
Abstract:
The models of both auxiliary partial orthotopic liver transplantation(APOLT)andacute liver failure were established.Acute liver failure in rats was successfully induced by partialhepatectomy of 75%with the remnant liver ischemia for 50 min.In treated group,the recipientsunderwent APOLT before the remnant liver(the right superior and inferior lobes)receiving tem-porary ischemia for 50 min.The experimental results showed that the 5-day survival rate of therats with acute liver failure was only 3%,while in the rats receiving APOLT,the 5-day survivalrate of the recipients and the liver graft was 80%and 73%,respectively.The liver function re-turned near tO normal level on the 5th postoperative day.It is suggested that acute liver failure in-duced by major liver resection with remnant liver ischemia in rat is an ideal model and APOLTmight provide an exact support for experimental acute liver failure in rat.
