Effect of IL-12 antibody on the survival of mouse heart graft
- VernacularTitle:IL-12抗体对小鼠心脏移植存活的影响
- Author:
Xiaofeng ZHU
- Publication Type:Journal Article
- Keywords:
Heart transplantation;
Mouse;
IL-12 antibody
- From:
Chinese Journal of Organ Transplantation
2000;21(4):216-217
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To establish the mouse heart transplantation model and observe the effect of anti-rejection of IL-12 antibody.Methods Twenty-five mice undergoing heterotopic heart graft were divided into 4 groups:isograft one(n=5),simple homograft one(n=6),γ-globulin treated one(n=6)and IL-12 antibody treated one(n=8).Results The survival time of cardiac graft in the groups was as follows:＞ 100 days in isograft group,7.3 days in simple homograft group,7.5 days in r-globulin treated group and 15.4 days in IL-12 antibody treated group.Conclusions A stable mouse heart transplantation modd was established.IL-12 antibody could significantly prolong the survival of mouse cardiac graft and antagonize rejection of organ transplantation.
