Therapeutic effects of tacrolimus substituting for cyclosporin in renal transplant recipients with hepatic dysfunction
- VernacularTitle:肾移植术后肝功能异常患者用他克莫司替换环孢素A疗效的初步观察
- Author:
Hongbo GUO
;
Yuhai ZHANG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Hepatic dysfunction;
Immunosuppressive agents
- From:
Chinese Journal of Organ Transplantation
2000;21(4):245-247
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of CsA substituted by tacrolimus(FK506) combined with MMF and prednisone in prevention of rejection in renal transplant recipents with hepatic dysfunction. Methods Eight patients with hepatic dysfunction received the treatment of FK506 substituting for CsA. FK506 was administeted at least 24 h after the last dose of cyclosporine.The initial dose of FK506 was based on body weight,the degree of hepatic dysfunetion and the period after operation of the patients.After administration of one week.the dose of FK506 was subsequently adjusted to maintain its whole blood trough levels between 5～15μg/L. Results Substitute of tacrolimus for cycbsporin resulted in a markedly reduced blood index,direct-bilirubin from(22.66±17.19)μmol/L to(7.05±2.32)μmol/L(P＜0.05), indirect-bilirubin from(42.15±34.15)μmol/L to(14.54±2.59)μmol/L(P＜0.05), sAL T from (83.00±93,14)IU/L to(29,50±15.41)IU/L(P＞0.05),Cr from (177.91±86.41)μmol/L to(135.92±34.05)μmol/L(P＞0.05)in one month.The ascites of 3 patients disappeared in one month. Astriction,anorexia,upper limbs trembling appeared only in one patient.Conclusion It is effective and safe to substitute CsA by FK506 combined with MMF and prednisone in prevention of rejection in renal transplant recipients with hepatic dvsfunction.
