Effects of genomic HLA-DR compatibility on long-term survival in first-cadaver kidney transplants
- VernacularTitle:HLA-DR基因相容对肾移植长期存活的影响
- Author:
Jianming TAN
;
Xiaoda TANG
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Histocompatibility;
HLA-DR
- From:
Chinese Journal of Organ Transplantation
2000;21(2):109-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of genomic HLA-DR compatibility on long-term survival in renal transplantation.Methods A retrospective study was performed on 518 first-cadaver renal transplants by using genotyping technique.Results More than 10%recipients shared HLA-DR matching at DNA level.half of 1 DR mismatches.The recipients with HLA-DR matched transplants showed a significant decrease of acute rejection episodes and a smooth recovery of early renal function as compared with those of DR mismatching kidneys.The 1 to 5 year-person survival rate was increased by 17%to 37.7% (P＜0.01)respectively.Multivariate analysis of 10 variables by Cox regression model revealed that DR mismatching was the most important factors influencing the long-term graft survival.Conclusion Genomic HLA-DR compatibility had a significant impact on long-term survival of first-cadaver kidney transplantation.
