The clinical observation of early micro-dose heparin in the children with systemic inflammatory reaction syndrome
- VernacularTitle:早期应用微量肝素治疗小儿全身炎性反应综合征的临床观察
- Author:
Jinghong YU
;
Shaofen YANG
;
Yanqing TU
- Publication Type:Journal Article
- Keywords:
Heparin;
Systemic mflnmmatory response syndrome;
Early stage
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(15):27-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effects of the children with svstemic inflammatorv re- active syndrome(SIRS)receiving micro-dose heparin at early stage of the diseases.Methods The 53 cas- es diagnosed as SIRS were included in the randomized control trial.They were divided into two groups,26 cases in control group and 27 cases in therapeutic group.The children in control group received therapy for their primary diseases and other routine managements for SIRS.The children in therapeutic group received both above therapy and micro-dose heparin(5-10 U/kg,1 fime/6hours)via subcutaneous injection at earlv stages of diseases for 3 days.Results There were improvements in both control and therapeutic group, platelets count increased,C-reactive protein decreased (P＜0.01),there were significant diffemnce in platelets and C-reactive protein between two groups,the time of platelets recovery in therapeutic group [(28±9)h]Was less than that in control group[(55±14)h](P＜0.01).In therapeutic group,the dumtion of SIRS was shortened (P＜0.05),mortality and the incidence of multiple organ dysfunction svndrome (MODS)and disseminated intravascular eoagultion(DIC)were decreased significantly(P＜0.05).Con- clusion Early micro-dose heparin in SIRS can shorten its duration and decrease the mortality and the inci- dence of MODS in the children with SIRS.
