Esophageal Ulcer Induced by Alendronate.
- Author:
Yong Hee JOUNG
1
;
Young Woon CHANG
;
Joo Young HAN
;
Byoung Wook LEE
;
Yo Seb HAN
;
Seok Ho DONG
;
Hyo Jong KIM
;
Byung Ho KIM
;
Joung Il LEE
;
Rin CHANG
Author Information
1. Department of Gastroenterology, Kyung Hee University College of Medicine, Seoul, Korea. cywgi@chollian.net
- Publication Type:Case Report
- Keywords:
Alendronate;
Esophageal ulcer
- MeSH:
Alendronate*;
Endoscopy, Digestive System;
Esophagitis;
Esophagus;
Female;
Follow-Up Studies;
Humans;
Korea;
Osteoclasts;
Osteoporosis, Postmenopausal;
Ulcer*
- From:Korean Journal of Gastrointestinal Endoscopy
2004;28(1):25-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Alendronate sodium (Fosamax(R)) is an aminophosphonate used in treatment of postmenopausal osteoporosis by inhibition of osteoclastic activity. Esophageal ulcers related to alendronate use have been reported at the rate of 2~6%. However, there have been no reports of esophagitis or esophageal ulcer by alendronate in Korea. We present a case of esophageal ulcer caused by alendronate. The patient presented with retrosternal pain and severe odynophagia for a few days. Esophagogastroduodenoscopy revealed multiple deep ulcers at the esophagus. Her symptoms resolved completely after stopping alendronate. A follow-up esophagogastroduodenoscopy 6 weeks later revealed complete healing of the ulcers.
