Memantine and Vascular Dementia
- VernacularTitle:美金刚与血管性痴呆
- Author:
Yongfu REN
;
Heyu LIU
- Publication Type:Journal Article
- Keywords:
memantine;
vascular dementia;
N-methyl-D-aspartate receptor
- From:
International Journal of Cerebrovascular Diseases
2008;16(4):289-292
- CountryChina
- Language:Chinese
-
Abstract:
Excitatory amino acid toxicity is one of the mechanisms of vascular dementia. Gluta-mate is the major excitatory neurotransmitter in brain. Memantine, a moderate affinity, uncom-petitive and voltage-dependent N-methyl-D-aspartate (NMDA) receptor blocker, can block NMDA receptor-induced intracellular calcium overload and prevent excitotoxicity. It can be used in the treatment of vascular dementia.
