Expression of Livin in small cell lung cancer and its correlation with p53
- VernacularTitle:Livin在小细胞肺癌中的表达及与p53相关性研究
- Author:
Bing SUN
;
Jinguang WANG
;
Lei HUANG
;
Jiliang LI
- Publication Type:Journal Article
- Keywords:
Inhibitor of apopto~sis proteins;
Carcinoma,small cell lung;
Genes,p53;
Im-munohistoehemistry;
Livin
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(14):15-18
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Livin and its relalionship with expression of p53 in small cell hmg cancer(SCLC).Methods Immunohistochemical S-P method was used to detect the ex-pression of Livin and p53 protein in 30 SCLC tissues and 16 para-cancerous lung tissues.Results Livin protein was expressed in 17 of 30 SCLC tissues(56.67%),but Livin protein showed low levels in para-can-cerous lung tissues(12.50%),P<0.01.There was no significant correlalion between positive Livin protein expression and age,sex,TNM staging,lymph node metastasis and lumor diameter(P>0.05).p53 protein was expressed in 14 of 30 SCLC tissues(46.67%),but p53 protein was no expressed in para-caneerous lung tissues,P<0.01.The expression of Livin protein was positively related to the expression of p53 protein(P<0.01).Conclusions The aberrant expression of Livin may be a new target for diagnosis and gene treatment of SCLC.The aberrant expression of Livin and p53 may play synergetic role in process of carcinogenesis of SCLC.