Nogo-A and Its Roles in Ischemic Cerebrovascular Disease
- VernacularTitle:Nogo-A及其在缺血性脑血管病中的作用
- Author:
Yan CHEN
;
Changqing LI
- Publication Type:Journal Article
- Keywords:
Nogo-A;
ischemic cerebrovascular disease;
neural regeneration
- From:
International Journal of Cerebrovascular Diseases
2008;16(4):313-316
- CountryChina
- Language:Chinese
-
Abstract:
Myelin-associated inhibitory factor is a major obstacle for axonal regeneration in the central nervous system, and Nogo-A is an important inhibiting factor synthesized by oligoden-drocytes. Toe expression levels of Nogo-A changed significantly in a model of ischemic cere-brovascular disease; the therapeutic measures aiming at Nogo-A and its downstream pathway can effectively enhance axonal regeneration, improve the plasticity of neural structure, and promote functional recovery. This provides a reliable theoretical basis for the development of therapeutic mode in human cerebrovascular diseases.
