Oligodendrocyte Degeneration and Alzheimer's Disease
- VernacularTitle:少突胶质细胞变性与Alzheimer病
- Author:
Gang LIU
;
Yingzhu CHEN
;
Heqing ZHAO
;
Shiyao BAO
- Publication Type:Journal Article
- Keywords:
oligodendrocyte;
Alzheimer's disease;
myelin sheath
- From:
International Journal of Cerebrovascular Diseases
2008;16(4):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Alzhelmer's disease (AD) is an important neurodegenerative disease. Recent evidence has indicated that the production and loss of the myelin,sheath are associated with AD because the particular vulnerability of oligodendrocytes produced in the late stage makes the loss of the myelin sheath take a core position in the changes of the earliest stage of AD. The loss of the myelin sheath disrupts synchronization of impulses on which normal brain functions highly depend, and ultimately results in the function disruption of cortical association regions and subsequent neuronal loss. Meanwfiile, there are diverse mechanisms that make oligodendrocytes degeneration exist in the brains of AD. Therefore, elucidating its specific mechanism may help better understanding of AD, and thus provide some help for its treatment.
