Matrix Metalloproteinases and Hemorrhagic Transformation
- VernacularTitle:基质金属蛋白酶与出血性转化
- Author:
Chenhui YANG
;
Hongguang FAN
;
Ying LIU
;
Xiangjian ZHANG
- Publication Type:Journal Article
- Keywords:
matrix metalloproteinase;
hemorrhagic transformation;
blood-brain barrier
- From:
International Journal of Cerebrovascular Diseases
2008;16(4):285-288
- CountryChina
- Language:Chinese
-
Abstract:
Thrombolysis can effectively treat ischemic stroke, but it has the risk of resulting in hemorrhagic transformation. A number of studies have suggested that hemorrhagic transforma-tion is closely correlated with matrix metalloproteinase mediated disruption of blood-brain barrier and the increase of vasopermeability. The increase plasma matrix metalloproteinase(MMP) -9 can be used as an independent predictor of hemorrhagic transformation. Using MMP inhibitors during the early cerebral ischemia may reduce the incidence and severity of hemor-rhagic transformation, however, it needs to be further validated.
