Effects of Fluvastatin on microalbuminuria of type 2 diabetes mellitus patients
- VernacularTitle:氟伐他汀对2型糖尿病患者尿微量白蛋白的影响
- Author:
Yunfeng SHEN
;
Xiaoyang LAI
;
Meiying ZHANG
;
Zelin LIU
;
Rong YU
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
Diabetic nephropathy;
Urinary albumin excretion rate;
Fluvastatin
- From:
Clinical Medicine of China
2008;24(6):526-528
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of fluvastatin on urinary albumin excretion rate(UAER)of microalbuminuria in type 2 diabetes patients.Methods Type 2 diabetes patients with mieroalbuminuria were randomly divided into fluvastatin goup(n=126)and control group(n=129).Fluvastatin group was given fluvastatin 40 mg each night.Follow up was conducted for 1.5 years.The UAER and glomerular filtration rate(GFR)as well as blood lipid level before and after therapy were compared.Results UAER in fluvastatin group was significantly lower than that in control group[(59.6±10.5)vs(87.5±12.3)mg/min,P＜0.05]before therapy[(104.4±25.2)vs(110.6±19.7)mg/min,P＜0.05],which was independent of its lowering-lipid effect.But GFR had no signifimicroalbuminuria which is independent of lowering-lipid effect in type 2 diabetic nephropathy patients and delay the progress of diabetic nephropathy.
