The effects of domestic irbesartan on blood pressure and renal function in the aged with primary hypertension
- VernacularTitle:国产厄贝沙坦对老年原发性高血压的疗效及对肾功能保护作用的研究
- Author:
Yi YANG
;
Feng CHEN
;
Yu YANG
;
Weidong GONG
;
Xiuhong LU
;
Wei LIU
;
Ruzi QIN
;
Cuiyun YIN
- Publication Type:Journal Article
- Keywords:
Aged;
Hypertension;
Beta 2-microglobulin;
Irbesartan
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(16):14-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of domestic irbesartan on blood pressure and renal function in the aged with primary hypertension.Methods Renal function,plasma and urine β2 microglob ulin WBS measured and blood pressure was investigated by 24-hour ambulatory blood monitoring in 42 aged with primary hypertension who received domestic irbesartan(1 50 mg/d,followed up every 1-2 weeks.If the effect was not ideal,the dose could be added to 300 mg/d)in 8-week's treatment.Results After the treatment.24 hours recall systolic blood pressure,24-hour mean diastolic blood pressure,mean day systolic blood pressure,mean day diastolic blood pressure,mean night systolic blood pressure,mean night diastolic blood pressure were significantly reduced.At the same time,domestic irbesartan induced a remarkable reduction of plasma and urine β2 microglobulin [(5.9±3.3)μg/L vs(2.6±2.6)μg/L, (811.2±97.2) mmol/L vs(457.6±69.8)mmol/L,respectively].Conclusion The antihypertensive effects of domestic irbesartan can persist for 24-hour and Can reduce urinary protein.
