Research on levels of IL-17,IL-4 and IFN-γ in induced sputum from pediatric patients with asthma
- VernacularTitle:白介素-17、白介素-4、干扰素-γ在小儿支气管哮喘诱导痰液中的表达及意义
- Author:
Xiangfeng YANG
;
Linxia CHEN
;
Zhiyong WU
- Publication Type:Journal Article
- Keywords:
Asthma;
Interleukin-4;
Interleukin-17;
Interferon type Ⅱ
- From:
Journal of Chinese Physician
2008;10(5):609-611
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the production of IL-17,IL-4 and IFN-γ in sputum of pediatric patients with asthma.Methods 61 pediatric patients with asthma in stage of exacerbation were enrolled as exacerbation group.and these patients in remission stage after therapy were enrolled as remission group, and 45 healthy children were chose as control group.The percentage of neutrophils and eosinophils were counted in regular way with sputum pigmentation,and the level of IL-17,IL-4 and IFN-γ were detected by enzyme-linked immunosorbent assay.Results IL-17 in exacerbation group Was highest among three groups, and IL-17 in remission group was higher than that in control group.In exacerbation group,IL-4 was higher and IFN-γ was lower than those in other two groups,and no significant difference Was found between remission group and control group.While in exacerbation stage,IL-17 was positive correlated with IL-4,and IFN-γ was negative correlated with IL-17 and IL-4.Conclusions IL-17 and IL-4 are related to the occurrence and exasperating of asthma,and IL-17 is suit for indicating the inflammation of asthma.IFN-γ is a protective factor of asthma.