Research of anti-keratin monocional antibody on animal's psoriasis
- VernacularTitle:抗角蛋白单克隆抗体对银屑病动物模型的作用研究
- Author:
Xiangping HU
;
Juan LIU
;
Zhaoyong AN
;
Shaomin LV
;
Fang CHEN
- Publication Type:Journal Article
- Keywords:
Keratin;
Antibodies,monoclonai;
Psoriasis
- From:
Journal of Chinese Physician
2008;10(5):615-617
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to explore the mechanisms of the anti-keratin monoclonal antibody 5G5(MAbSG5)in psoriasis treatment.Methods The different groups of mouse were fed with 5G5.The effect on regulating keratinocyte proliferation was observed.Results The experimental study revealed that MAb5G5 has the function of restraining the karyokinesis of vagina epithelium and accelerating the formation of stratum granulosum in rat squamous epidermis.Conclusion The mechanism of MAb5G5 in psoriagis treatment may be related to regulate keratinocyte proliferation.
