Effect of high viral hepatitis B virus DNA loads on vertical transmission of hepatitis B virus in late-pregnant women
- VernacularTitle:拉米夫定对乙型肝炎病毒阳性孕妇母婴垂直传播的影响
- Author:
Song YANG
;
Min LIU
;
Ling WANG
- Publication Type:Journal Article
- Keywords:
Pregnancy complications,infectious;
Hepatitis B virus;
DNA,viral;
Viral load;
Disease transmission,vertical
- From:
Chinese Journal of Obstetrics and Gynecology
2008;43(5):329-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of high viral loads(HBV DNA concentration in blood ＞2.0 copy/ml)on the vertical transmission of hepatitis B virus in mothers with HBV DNA positivity.Method Forty pregnant women with HBV DNA positivity were divided randomly.double-blindly into 2 groups:at 28 weeks of pregnancy,one group received oral lamivudine(100 mg/d)and the other received oral placebo.The serum HBV DNA loads were tested at 28 and 40 weeks'gestation in mothers,and serum HBV DNA,HBsAg,HBeAg and anti-HBs were examined in infants at 12 month follow up.Result Thirtynine infants finished(one twins)the follow up,and 2 infants lost(5%).Among them 4 infants were confirmed to be HBV infection(10%,4/39),2 in the treatment group(10%,2/20)and 2 in the control group(11%,2/19)(P＞0.05).The serum HBV DNA levels of 40 weeks'gestation in the treatment group,compared with the levels of 28 weeks'gestation in the treatment group and 40 weeks'gestation in the control group,showed a significant decline(P＜0.01).The HBV DNA levels of the mothers whose infants were infected,were(3.1±3.4) copy/ml,(3.1±3.2) copy/ml during 28 and 40 weeks'gestation,and for mothers whose infants were non-infected,the levels were(3.4±2.2) copy/ml,(2.6±1.5) copy/ml respectively(P＞0.05).The mean values of anti-HBs of 18 infants in the treatment group showed no significant difference as compared to 17 infants in the control group,(594±416)U/L vs (458±398) U/L (P＞0.05).Conclusion The pregnant women's HBV DNA loads could be obviously decreased from high viral loads (HBV DNA concentrations in blood＞2.0 copy/ml)after they take lamivudine from 36 weeks'gestation.But it might not reduce the maternal-fetal vertical transmission of HBV infection.
