Cationic Trypsinogen Gene Mutation in Patients with Chronic Idiopathic Pancreatitis.
- Author:
Woo Jin LEE
1
;
Kyung Ah KIM
;
June Sung LEE
;
Young Bin JEON
;
Ji Bong JEONG
;
Ji Kon RYU
;
Yong Tae KIM
;
Yong Bum YOON
;
Chung Yong KIM
Author Information
1. Center for Liver Cancer, National Cancer Center, Goyang, Korea.
- Publication Type:Original Article ; English Abstract
- Keywords:
Cationic trypsinogen gene;
Pancreatitis;
chronic idiopathic;
Pancreatitis;
hereditary
- MeSH:
Adolescent;
Adult;
Chronic Disease;
English Abstract;
Female;
Humans;
Male;
Middle Aged;
*Mutation;
Pancreatitis/*genetics;
Polymerase Chain Reaction;
Trypsin/*genetics;
Trypsinogen/*genetics
- From:The Korean Journal of Gastroenterology
2004;43(1):41-46
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Mutation of Cationic trypsinogen gene is clearly associated with hereditary pancreatitis and plays an important role in the pathogenesis of pancreatitis. According to literature, this mutation is occasionally occurred in patients with pancreatitis in Western countries and Japan. The aim of this study was to find out whether the mutation was observed in Korean patients with chronic idiopathic pancreatitis. METHODS: Peripheral blood samples of 11 patients with chronic idiopathic pancreatitis were collected consecutively, and DNA was extracted from the samples. Polymerase chain reaction was performed in exon 2 and 3 of cationic trypsinogen gene. Then, DNA products were purified and sequenced. RESULTS: The mutation was not found in exon 2 and 3 of cationic trypsinogen gene in these patients. CONCLUSIONS: There was no cationic trypsinogen mutation in Korean patients with chronic idiopathic pancreatitis. Further large sampled cohort study is needed.
