Expression of multidrug resistance-related proteins MRP1/LRP/GST-π in carcinoma of the gallbladder and cholangiocarcinoma
- VernacularTitle:肿瘤多药耐药蛋白MRP1、LRP和GST-π在胆囊和胆管癌组织中的表达
- Author:
Yunjie JIN
;
Houbao LIU
;
Zhenbin SHEN
;
Saixiong TONG
;
Bingsheng WANG
- Publication Type:Journal Article
- Keywords:
Gallbladder neoplasms;
Bile duct neoplasms;
Muhidrug resistance-associated proteins;
Lung resistance-related protein: Glutathione S transferase-π
- From:
Chinese Journal of General Surgery
2008;23(5):356-359
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of muhidrug resistance-related protein 1 (MRP1),lung resistance-related protein(LfuP)and glutathione S-transferase-π(GST-π)in carcinoma of the gallbladder and cholangiocarcinoma. Methoils MRP1,LRP,GST-πwere measured in experimental group(18 cases of carcinoma of the gallbladder,36 CSSeS Of cholangiocarcinoma)and control group(13cases of cholecystitis and cholangeitis)by immunohistochemistry.Statistical analysis used chi-square test and spearman test. Results The positive rate of MRP1,LRP,GST-π in carcinoma of the gallbladder and eholangiocarcinoma were 72%(13/18),78%(14/18),61%(11/18)and 86%(31/36),75%(27/36),69%(25/36),respectively,significantly higher than those of 23%(3/13),23%(3/13),23%(3/13)(X2=4.5,P＜0.05)in control group.The expression of LRP[93%(13/14)]in pafients＞60 years old was significantly higher than 64%(14/22)in patients younger than 60 yrs old(x2=3.9,P ＜0.05).In addition,their expression was not related to gender,age,staging,tumor differentiation and lymph node metastasis(P＞0.05).The expression of MRP1 was related with tllose Of GST-π,Spearman correlation coefficient=0.569(P＜0.05).Conclusions MRP1,LRP,GsT-π were over expressed in various degrees in carcinoma Of the gallbladder and cholangiocarcinoma witllout chemotherapy.and related to the primary muhidrug resistance Of cholangiocarcinoma and carcinoma of the gallbladder.
