The effect of HIFU ablation combined with UCA on normal tissue around VX2 liver tumor in rabbits
- VernacularTitle:高强度聚焦超声联合超声造影剂消融肝脏VX2移植瘤的实验研究
- Author:
Zhiyong FAN
;
Zhenshun SONG
;
Wei ZHENG
;
Sheng HUANG
;
Fuqin ZHANG
;
Wen LUO
;
Xiaodong ZHOU
- Publication Type:Journal Article
- Keywords:
Neoplasms,experimental;
Ultrasonic therapy;
Contrast media
- From:
Chinese Journal of General Surgery
2008;23(5):364-367
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the optimized range of normal tissue ablation around the tumor by HIFU in combination with UCA for VX2 liver tumors in rabbits. Methods In this study,51 rabbit models with implanted fiver VX2 tumors were randomly divided into 3 groups:ablating the tumor only(group A)、ablating the tumor and 2 mm eircumferential normal tissue(group B)、and 4 mm normal tissue around the tumor(group C).After HIFU+UCA treatment,the pathology of the targeting tissues,the level of serum ALT,the metastases in the liver、lungs and abdominal cavity,and the survival time were compared with each other. Results After treatment coagulative necrosis was observed in all the target tissues.Serum ALT level between each two groups were statistically different on d3 and d5(F=12.933、18.37,P＜0.01、＜0.01),and the level of ALT in group C was the hightest.The ALT level in group A was significantly higher than group B or group C on the 14th day(F=17.2,P＜0.01).Metastases in group A was significantly higher than group B or group C,and there were no statistically different between group B and C (P=0.353、0.332、0.380).The survival time both in group B and group C were significantly longer than group A(48±13.6,51±12.1 vs 29±5.4),and there were no statistically difference between group B and C(P＞0.05). Conclusions Tumor eradication can be significantly promoted when 2mm normal liver tissue around the tumor is ablated by HIFU+UCA.
