Expression and significance of P-JNK and mutlidrug resistance protein in gastric cancer
- VernacularTitle:c-jun氨基末端激酶与多药耐药蛋白在胃癌组织中的表达及其意义
- Author:
Dawei LI
;
Zhihai PENG
;
Weiyi HUANG
;
Zhaorui YANG
;
Qing WU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Muhidrng resistance-associated proteins;
N-terminal kinase
- From:
Chinese Journal of General Surgery
2008;23(5):376-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathogenical significance of phosphorylation type of c-jun N-terminal kinase(p-JNK)and muhidmg resistance protein P-glycopretein(P-gP),multidrug resistance proteinl(MRP1)and lung resistance protein(LRP)in gastric cancer. Methods The expression of p-JNK,P-gP,MRP1 and LRP was detected in a tissue microarray containing 168 spots of gastric cancer tissue and 27 spots of normal gastric tissue by immunohistochemistry.Results The positive expression rate of p-JNK,P-gp,MRP1 and LRP in gastric cancer wag 45.8%,51.8%,45.8%and 55.4%respectively,which Was significantly higher than that in normal gastric tissue(P＜0.05).The p-JNK expression correlated with depth of invasion(P＜0.01),histology grade(P＜0.05),vessel invasion (P＜0.01),lymph node metastasis and distant metastasis(P＜0.01).The expression of p-JNK,P-gp and MRP1 in a positive relationship(P＜0.05).Kaplan-Meier analysis revealed a significant impact on survival by p-JNK,P-gp and MRPl(P＜0.05). Conclusion The p-JNK expression in gastric cancer is correlated with malignant biological behavior and may be involved in the chemotherapeutic resistance by upregulating the expression of P-g[ and MRP1.
