Expression of cellular FLICE-inhibitory protein in peripheral blood and lesions of patients with psoriasis
- VernacularTitle:凋亡抑制蛋白c-FLIP在银屑病患者外周血和皮损中的表达
- Author:
Juan TAO
;
Yan LI
;
Jing DONG
;
Lin WANG
;
Yeqiang LIU
;
Jing YANG
;
Yating TU
- Publication Type:Journal Article
- Keywords:
Psoriasis;
Apoptosis proteins inhibitor;
Apoptosis
- From:
Chinese Journal of Dermatology
2008;41(6):377-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression and distribution of cellular FLICE-inhibitory protein (c-FLIP) in peripheral blood and lesions of psoriatic patients. Methods Peripheral blood and skin samples were obtained from 30 patients with psoriasis vulgaris and 20 normal controls. Flow cytometry was used to detect intracellular c-FLIP protein in peripheral T and B lymphocytes, immunohistochemistry to examine the expression of c-FLIP in lesional tissue. Results Based on the positivity rate of c-FLIP, there was a significant increase in T lymphocytes in active psoriasis compared with regressive psoriasis and normal controls (6.32%±1.17% vs 2.64%±0.74% and 2.28%±0.54%, P＜0.01 and 0.05, respectively), while no significant difference was found in B lymphocytes among these three groups (0.78%±0.16%, 0.71%±0.32%, 0.69%±0.18%, respectively, P＞0.05). The expression intensity of c-FLIP in keratinocytes was also higher in active psoriasis than in regressive psoriasis and normal controls (89.73±5.24 vs 117.40±7.50,121.58±7.93, P＜0.01 and 0.05 respectively), and there was no difference between regressive psoriasis and normal controls (P＞0.05). Conclusions c-FLIP is highly expressed in lesions and peripheral T lymphocytes of patients with active psoriasis, suggesting the possible involvement of c-FLIP in the proliferation of T lymphocytes in psoriasis.
