A Case of Sarcomatoid Combined Hepatocellular-Cholangiocarcinoma.
- Author:
Bong Ju JEONG
1
;
Dong Hyo HYUN
;
Kyoung Wook LEE
;
Sung Tae RYU
;
Jin Woo LEE
;
Jung Il LEE
;
Seok JEONG
;
Don Hang LEE
;
Pum Soo KIM
;
Hyung Gil KIM
;
Young Soo KIM
;
Jun Mee KIM
Author Information
1. Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea. jin@inha.ac.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Combined hepatocellular-cholangiocarcinoma;
Sarcomatoid;
Liver
- MeSH:
Bile Duct Neoplasms/*pathology;
*Bile Ducts, Extrahepatic;
Carcinoma, Hepatocellular/*pathology;
Cholangiocarcinoma/*pathology;
English Abstract;
Female;
Humans;
Liver Neoplasms/*pathology;
Middle Aged;
Sarcoma/*pathology
- From:The Korean Journal of Gastroenterology
2004;43(1):56-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Combined hepatocellular-cholangiocarcinoma (HCC-CC) with sarcomatoid features is an extremely rare primary liver cancer, of which only four cases have been reported. We report a case of sarcomatoid combined HCC-CC in a 60-year-old woman who complained of right upper quadrant pain and presented with a 7 cm mass in the S4 region of the liver in abdominal CT. Ultrasonography-guided needle biopsy diagnosed it as HCC, and left lobectomy of the liver followed. Microscopically, the tumor consisted of two portions: HCC portion showing trabecular pattern, which had partially sarcomatous area with spindle-shaped tumor cells, and CC portion with glandular pattern. Immunohistochemically, HCC portion reacted positively with alpha-fetoprotein while CC portion demonstrated positive reactivity with carcinoembryonic antigen and mucicarmine. Sarcomatoid cells reacted positively for cytokeratin. She died of tumor recurrence and hepatic failure 12 months after the operation. Combined HCC-CC has poor prognosis, and sarcomatoid HCC has high metastatic potential and poor prognosis compared with ordinary HCC.
