Diagnosis and treatment of multiple insulinom
- VernacularTitle:多发性胰岛素瘤的诊断与治疗
- Author:
Lin CONG
;
Yupei ZHAO
;
Taiping ZHANG
;
Quan LIAO
;
Menghua DAI
;
Ge CHEN
;
Ziwen LIU
;
Ya HU
;
Junchao GUO
;
Yingchi YANG
;
Lixing CAI
;
Yu ZHU
- Publication Type:Journal Article
- Keywords:
Insulinoma;
Multiple endocrine neoplasm type 1;
Diagnosis;
Treatment
- From:
Chinese Journal of General Surgery
2008;23(5):336-339
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the diagnostic and therapeutic experiences for multiple insulinoma. Methods Clinical data of 34 cKsefl of multiple insulinoma treated in Peking Union Medical College Hospital between 1984 and 2007 were analyzed retrospectively. Results Multiple insulinoma was identified in these 34 cases for 37 instances.Malignant insulinoma was found in 2 cases.Three cases suffered from postoperative recurrent multipie tumors.35.3% cases belonged to MEN1;13.5% cases were of insulinoma combined with islet hyperplasia;43.2% cases had 3 or more than 3 insulinomas;Fifteen cases (40.5%)had had a misdiagnosis.45.2%tumors were smaller than 1 cm in diameter:88.9%multiple insulinonla located at the body and tail of the pancreas.Enucleation of multiple tumors was performed for 48.7 percent of cases. Conclusions Most multiple insulinomas were small,it was difficult for preoperative examination to locate all the tumors therefore.Being on the alert against multiple insulinoma and such measures as careful exploration,intraoperative blood glucose determination.fine needle aspiration biopsy,frozen sections helps to avoid missing multiple imuhnoma.
