Research on the level of serum leptin and tumor necrosis factor-a in children with obstructive sleep apnea-hypopnea syndrome
- VernacularTitle:阻塞性睡眠呼吸暂停低通气综合征患儿血清瘦素和肿瘤坏死因子-α水平的变化
- Author:
Yi JIAN
- Publication Type:Journal Article
- Keywords:
Sleep apnea,obstructive;
Leptin;
Tumor necrosis factor-alpha
- From:
Journal of Chinese Physician
2008;10(5):617-619
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the change of the serum leptin and tumor necrosis factor-α levels in children with obstructive sleep apnea-hypopnea syndrome and their relationship.Methods The level of serum leptin and TNF-α were determined in 68 children with obstructive sleep apnea-hypopnea syndrome and 30 healthy children by radio-immunity assay,and the results from patients treated with continuous positive airway pressure(CPAP)for six months were compared.The correlation between leptin and the levels of tumor necrosis factor-α,and apnea hypopnea index(AHI)or the minimum saturation of bloed oxygen were analyzed.Results The level of leptin and tumor necrosis factor-α in OSAHS patients were hisher than those in control(P＜0.05).The levels of leptin and tumor necrosis factor-αwere positive correlated with the AHI(r=0.451,r=0.460,P＜0.05)and negative correlated with the minimum saturation of blood oxygen(r=-0.489.r=-0.478,P＜0.05).The levels of leptin and tumor necrosis factor-α were decreased after treatment.Conclusion The levels of leptin and tumor necrosis factor-α are increased in OSAHS children.The increase of leptin and tumor necrosis factor-α is correlated with hypoxemia,and the levels of leptin and tumor necrosis factor-α can be improved by CPAP in OSAHS children.
