Meta analysis of the rate of urethral stricture after treatments of posterior urethral injuries
- VernacularTitle:后尿道损伤不同术式处理后尿道狭窄发生率的Meta分析
- Author:
Renbin YUAN
;
Qiang WEI
;
Tao LI
- Publication Type:Journal Article
- Keywords:
Pelvic fractures;
Urethral inj uries;
Urethral stricture;
Meta analysis
- From:
Chinese Journal of Urology
2008;29(6):392-395
- CountryChina
- Language:Chinese
-
Abstract:
0bjective To determine the effect of 2 therapies(early realignment versus delayed open urethroplasty)for posterior urethral injuries associated with pelvic fractures. Methods A sys-tematic review of all the relevant clinical trials was performed.Trials were identified from specialized trials register of Cochrane UGDP Group,the Coehrane library,additional electronic search(mainly MEDLINE、EMBSAE、CBM)and manual searching.Clinical trials comparing early realignment and delayed open urethroplasty of posterior urethral disruption associated with pelvic fractures were includ-ed.Statistics analysis was managed by using Review Manager 4.2. Results Ten clinical trials inclu-ding 470 patients were included.Meta-analysis indicated that odds ratio(OR)of the rate of urethral stricture was 0.27[95%confidence interval(95%CI)0.08,0.86,P=0.03].The OR of the percent-age of strictures needing urethroplasty was 0.25,95%CI 0.08,0.74,P=0.01. Conclusions Early realignment may provide better outcomes than delayed open urethroplasty after posterior urethral dis-ruption.It can decrease urethral stricture formation and the percentage of strictures needing urethro-plasty.But the results might be influenced by the bias of grouping,especially the severity of injuries.
